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Tiled-ClickSeq Publications
Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants:
Tiled-ClickSeq leverages the ClickSeq approach to perform complete genome or gene sequencing. Using multiple tiled primers, overlapping amplicons spanning the target are generated. Tiled-ClickSeq has been optimized for the whole genome sequencing of RNA viruses including SARS-CoV-2.
Vu, M. N.; Lokugamage, K. G.; Plante, J. A.; Scharton, D.; Bailey, A. O.; Sotcheff, S.; Swetnam, D. M.; Johnson, B. A.; Schindewolf, C.; Alvarado, R. E.,
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis.
Johnson, B. A.; Zhou, Y.; Lokugamage, K. G.; Vu, M. N.; Bopp, N.; Crocquet-Valdes, P. A.; Kalveram, B.; Schindewolf, C.; Liu, Y.; Scharton, D., Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Muruato, A.; Vu, M. N.; Johnson, B. A.; Davis-Gardner, M. E.; Vanderheiden, A.; Lokugamage, K.; Schindewolf, C.; Crocquet-Valdes, P. A.; Langsjoen, R. M.; Plante, J. A.,
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Johnson, B. A.; Xie, X.; Bailey, A. L.; Kalveram, B.; Lokugamage, K. G.; Muruato, A.; Zou, J.; Zhang, X.; Juelich, T.; Smith, J. K.,
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Jaworski, E.; Langsjoen, R. M.; Mitchell, B.; Judy, B.; Newman, P.; Plante, J. A.; Plante, K. S.; Miller, A. L.; Zhou, Y.; Swetnam, D.,
Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants.
